Anna had seven children; she participated in governing of the country by greatly supporting her husband and later her son Friedrich. Anna efficiently managed her property. She was against excessive luxury and extravagance in the Duchy of Courland and therefore issued a regulation on festivities and dress.
Anna is buried in a pewter sarcophagus with engraved scene of resurrection of Christ and the coats of arms of Mecklenburg, Pomerania-Wolgast, Brandenburg and Denmark. The restoration of the sarcophagus was completed and the burial was consecrated in 2014.